Mata Kuliah BI4111 - 2024

Kode Mata KuliahBI4111 / 3 SKS
Penyelenggara106 - Biologi / SITH
KategoriKuliah
Bahasa IndonesiaEnglish
Nama Mata KuliahPengembangan Diagnostik MolekularMolecular Diagnostic Development
Bahan Kajian
  1. Dasar-dasar diagnostik molekular, precision medicine, etika, dan regulasi
  2. Manajemen spesimen, ekstraksi asam nukleat, dan pengendalian mutu
  3. Prinsip PCR, desain primer, dan optimasi amplifikasi
  4. qPCR, digital PCR, dan analisis data kuantitatif
  5. Teknik amplifikasi isotermal (LAMP dan RPA)
  6. Sekuensing Sanger dan analisis mutasi
  7. Next-Generation Sequencing (NGS) dan bioinformatika dasar
  8. Diagnostik molekular penyakit infeksi dan resistensi antimikroba
  9. Onkologi molekular, liquid biopsy, dan biomarker kanker
  10. Penyakit genetik, farmakogenomik, dan diagnostik berbasis CRISPR
  11. Validasi metode, penjaminan mutu, dan pemantapan mutu eksternal
  12. Regulasi, pengembangan produk, dan komersialisasi diagnostik molekular
  1. Fundamentals of molecular diagnostics, precision medicine, ethics, and regulations
  2. Specimen management, nucleic acid extraction, and quality control
  3. PCR principles, primer design, and assay optimization
  4. qPCR, digital PCR, and quantitative data analysis
  5. Isothermal amplification techniques (LAMP and RPA)
  6. Sanger sequencing and mutation analysis
  7. Next-Generation Sequencing (NGS) and basic bioinformatics
  8. Molecular diagnostics for infectious diseases and antimicrobial resistance
  9. Molecular oncology, liquid biopsy, and cancer biomarkers
  10. Genetic disorders, pharmacogenomics, and CRISPR-based diagnostics
  11. Method validation, quality assurance, and external quality assessment
  12. Regulatory affairs, product development, and commercialization of molecular diagnostics
Capaian Pembelajaran Mata Kuliah (CPMK)
  1. Mahasiswa mampu menjelaskan konsep, prinsip, dan perkembangan teknologi diagnostik molekular serta perannya dalam diagnosis penyakit, precision medicine, dan pelayanan kesehatan
  2. Mahasiswa mampu menerapkan teknik preparasi spesimen, ekstraksi asam nukleat, pengendalian mutu, serta metode amplifikasi dan sekuensing molekular sesuai prinsip laboratorium yang baik
  3. Mahasiswa mampu menganalisis dan menginterpretasikan data hasil pemeriksaan diagnostik molekular menggunakan berbagai teknologi, seperti PCR, qPCR, dPCR, sequencing, dan Next-Generation Sequencing (NGS), untuk identifikasi penyakit infeksi, genetik, dan kanker
  4. Mahasiswa mampu mengevaluasi validitas hasil pemeriksaan diagnostik molekular berdasarkan parameter kualitas, validasi metode, aspek regulasi, serta perkembangan teknologi dan hilirisasi produk diagnostik
  1. Students are able to explain the fundamental concepts, principles, and recent advances in molecular diagnostics, as well as their applications in disease diagnosis, precision medicine, and healthcare
  2. Students are able to apply appropriate techniques for specimen management, nucleic acid extraction, quality control, amplification, and sequencing in accordance with good laboratory practices
  3. Students are able to analyze and interpret molecular diagnostic data generated using PCR, qPCR, digital PCR (dPCR), Sanger sequencing, and Next-Generation Sequencing (NGS) for the diagnosis of infectious diseases, genetic disorders, and cancer
  4. Students are able to evaluate the validity and reliability of molecular diagnostic methods based on quality assurance, method validation, regulatory requirements, and the translation of diagnostic technologies into clinical and commercial applications
Metode PembelajaranPerkuliahan, Diskusi Kelas/Kelompok, dan Praktikum LaboratoriumLectures, Class/Group Discussions, and Laboratory Practicals
Modalitas PembelajaranLuring/Daring, Sinkron, Mandiri/KelompokOffline/Online, Synchronous, Independent/Group
Jenis NilaiABCDE
Metode PenilaianPenilaian terdiri atas keaktifan dan diskusi kelas (10%), tugas desain primer menggunakan perangkat bioinformatika (15%), laporan praktikum atau analisis jurnal (20%), Ujian Tengah Semester (25%), dan Ujian Akhir Semester (30%)Assessment consists of participation and class discussions (10%), a primer design assignment using bioinformatics tools (15%), laboratory reports or journal analysis (20%), the Midterm Examination (25%), and the Final Examination (30%)
Catatan Tambahan