Kurikulum 2024

Kode Mata KuliahFA3211 / 2 SKS
Penyelenggara107 - Pharmaceutical Science and Technology / SF
KategoriLecture
Bahasa IndonesiaEnglish
Nama Mata KuliahKimia MedisinalMedicinal Chemistry
Bahan Kajian
  1. Aspek farmakokinetik obat, metabolisme obat, aspek fisiko-kimia obat
  2. Target dan mekanisme kerja obat serta signal transduction
  3. Strategi dalam penemuan senyawa aktif/pemandu
  4. HSA dan HKSA, kimia kombinatorial, desain obat rasional dan computer aided drug design (CADD) dan optimisasi lead
  5. Pengembangan dan produksi obat
  6. Obat yang dikembangkan melalui desain rasional: cimetidin, obat kolinergik dan adrenergik, obat antibakteri, analgesik opium, obat anti radang
  1. Pharmacokinetic aspects of drugs, drug metabolism, physico-chemical aspects of drugs
  2. Drug targets and mechanisms of action as well as signal transduction
  3. Strategies in the discovery of active/lead compounds
  4. SAR and QSAR, combinatorial chemistry, rational drug design and computer aided drug design (CADD) and lead optimization
  5. Drug development and production
  6. Rational drug design: cimetidine, cholinergic and adrenergic drugs, antibacterial, opium analgesics, anti-inflammatory drugs
Capaian Pembelajaran Mata Kuliah (CPMK)
  1. Mampu menjelaskan landasan ilmiah senyawa yang berfungsi sebagai obat dan target kerja obat
  2. Mampu menjelaskan prinsip dasar yang melandasi terjadinya aktivitas biologi
  3. Mampu menjelaskan kaitan antara struktur molekul dan karakteristik fisikokimia suatu molekul obat
  4. Mampu menjelaskan fitur struktur target kerja obat yang berperanan dalam interaksi obat dan target kerja obat
  5. Mampu menjelaskan respon mekanisme kerja obat berdasarkan terjadinya interaksi obat dan target kerja obat serta respon selular dan peristiwa signal tranduction yang mengikutinya.
  6. Mampu menjelaskan strategi dalam penemuan (discovery) senyawa aktif/lead dengan pendekatan modifikasi struktur obat yang sudah ada (Synthetic analogues), penapisan sistematik, pemanfaatan informasi biologis, dan strategi rasional
  7. Mampu menjelaskan contoh desain obat rasional berbasis computer aided drug design (CADD) dengan pendekatan ligand-based ligand design (LBLD) dan structure-based ligand design (SBLD).
  1. Able to explain the scientific basis of compounds that function as drugs and drug targets
  2. Able to explain the basic principles underlying biological activities
  3. Able to explain the relationship between molecular structure and physicochemical characteristics of a drug molecule
  4. Able to explain the features of the drug target structure that plays a role in drug interaction and drug target
  5. Able to explain the response of the drug action mechanism based on the occurrence of drug interactions and drug action targets as well as cellular responses and signal transduction events that follows.
  6. Able to explain strategies in the discovery of active compounds/leads with the approach of modifying existing drug structures (Synthetic analogues), systematic filtering, utilization of biological information, and rational strategies
  7. Able to explain examples of rational drug design based on computer aided drug design (CADD) with ligand-based ligand design (LBLD) and structure-based ligand design (SBLD) approaches.
Metode PembelajaranPembelajaran, kerja kelompok, kerja mandiriLecture, group assignment, self-directed task
Modalitas PembelajaranBahan ajar (salindia/video pembelajaran), studi kasus, topik-topik khusus kajianVisual and auditorial, case studies, special topic
Jenis NilaiABCDE
Metode PenilaianUjian tertulis, karya tulis, presentasiWritten exam, report/article, presentation
Catatan Tambahan